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The TSA software is free of charge and can be downloaded here. Below are some publications where the use of the TSA software is illustrated. You are welcome to use it in your analyses and publications of cumulative meta-analyses with proper reference to the software and some of our articles describing the methodology. Additionally, TSA provides us with important information regarding the required sample size for such trials.
#COMPREHENSIVE META ANALYSIS MAC下载 TRIAL#
In TSA the addition of each trial in a cumulative meta-analysis is regarded as an interim meta-analysis and TSA controls the risks for type I and type II errors and helps to clarify whether additional trials are needed. Sequential monitoring boundaries can be applied to meta-analysis as well, called trial sequential monitoring boundaries. To avoid type I errors, group sequential monitoring boundaries are applied to decide whether a trial could be terminated early because of a sufficiently small P-value, that is if the cumulative Z-curve crosses the monitoring boundaries (1). In a single trial, interim analyses increase the risk of type I errors. Bias from trials with low methodological quality, outcome measure bias, publication bias, early stopping for benefit, and small trial bias may result in spurious P-values. Meta-analysis may result in type I errors due to systematic errors (bias) or random errors (play of chance) due to sparse data and repeated significance testing when updating meta-analysis with new trials. TSA is a tool for quantifying the statistical reliability of data in the cumulative meta-analysis adjusting significance levels for sparse data and repetitive testing on accumulating data. TSA is a methodology that combines an information size calculation (cumulated sample sizes of all included trials) for a meta-analysis with the threshold of statistical significance. Trial Sequential Analysis (TSA) is a user-friendly software application which makes it easy for authors of systematic reviews and meta-analysis to apply a number of advanced sequential hypothesis testing techniques to their meta-analyses.
#COMPREHENSIVE META ANALYSIS MAC下载 MANUAL#
The Trial Sequential Analysis (TSA) Manual is available for download in English, Chinese, and Spanish.
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